Individual study plan

Disposition

• Introduction and Background: Introduction to the topic, research objectives

• Research plan and Methodology: Study designs, methods and analysis

• Timeline and Milestones: Project timeline with key milestones

• Resources and Support: Overview of resources and support

• Discussion and Feedback: Opportunity for audience feedback
  

Introduction and Background

Relevance

Introduction and Background

Relevance

Key Areas: Cardiovascular disease, diabetes, heart failure, sepsis

Clinical Implications

Early Detection and Prevention: Monitoring microvascular function helps identify patients at high risk, enabling early intervention and preventive measures.

Disease Progression and Treatment Monitoring: Microvascular assessment provides a window into disease activity, aiding in the evaluation of treatment effectiveness.

Goal-Directed Therapy: Insights into microvascular health support goal-directed therapies, optimizing treatment plans tailored to individual needs.

Introduction and Background

Problem

Current methods

Capillary refill time Subjectivity, variability, sens/spec, non-quantifiable*

Coronary angiography Invasive, cumbersome, resource intensive, organ specific

Stress Cardiac MRT Cumbersome, resource intensive, organ specific

Biomarkers Analysis time, interpretation, resource intensive

Introduction and Background

Problem

Future methods - what is needed?

Quantitative Precision and comparison

Non-invasive Risk and discomfort

Low variability and High sensitivity Consistency and precision

Rapid and ease of use Clinical convenience

Organ-agnostic Systemic dysfunction

Cost-effective Iterative usage and goal-directed

Research Plan and Methodology

• The CapriS Study, Capillary Dysfunction in Sepsis
  • Patients with severe sepsis or septic shock
    • Rapid microvascular decompensation
• The MIND Study, Microangiopathy in Diabetes
  • Patients with type 1 diabetes, with and without clinical microangiopathy
    • Chronic microvascular deterioration
• SCAPIS2Spectrum, Microcirculation Substudy
  • Patients with high risk of cardiac microangiopathy
    • Microangiopathy in different populations

Timeline and Milestones

gantt
    dateFormat YYYY-MM
    section Mandatory courses
        Medical Research Ethics                     :active               2025-01, 2025-02
        Basic Laboratory Safety                     :active               2025-01, 2025-02
        Introduction to Doctoral Education at KI    :active               2025-01, 2025-02
        Basic Course in Medical Statistics          :active               2025-02, 2025-03
        Present your Research!                      :active               2025-08, 2025-09
        Quality Assurance of Clinical Research      :active               2025-09, 2025-10
    section Project specific courses
        Statistical Methods with R                  :active               2024-09, 2024-12
        Programing in Python                        :active               2024-08, 2024-11
        Endothelial Cell Function[...]              :active               2026-02, 2026-03
        Intermediate Medical Statistics             :active               2026-03, 2026-04
        Cellular Signalling                         :active               2026-04, 2026-05
    section Studies
        Microangiopathy IN Diabetes(MIND)           :active               2024-01, 2027-06
        Capillary dysfunction in Sepsis(CapriS)     :active               2024-01, 2028-06
        SCAPIS2Spectrum - Microcirculation substudy :active               2024-03, 2029-01
    section Conferences
        European Society on Microcirculation        :active, milestone    2025-05, 2025-06
        ISICEM                                      :active, milestone    2026-03, 2026-04
        European Society on Microcirculation        :active, milestone    2027-04, 2027-05
    section Journal clubs
        IMA-Journal Clubs                           :active, crit,        2024-08, 2029-05
    section Milestones
        Start date                                  :milestone,           2024-08, 2024-08
        Half-Time Control                           :milestone,           2026-08, 2026-08
        Dissertation Defense                        :milestone, crit,     2029-05, 2029-05

Resources and Support

• Supervisor: Sara Tehrani, MD, PhD, MICU specialist
• Co-Supervisor: Dr. Maria Cronhjort, MD, PhD, anesthesiologist and ICU specialist

• Courses and Education

• KFC-Statistician

• Research seminars

Challanges and Risk Management

• Large Scale Studies
  • Participant Scheduling
    • Automatic scheduling system
  • Data Collection
    • Partially automatic data collection and integrity system
• Data Analysis Phase
  • Well-defined analytic aims
  • Specific courses

Discussion and Feedback